Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor
نویسندگان
چکیده
منابع مشابه
Ca2+ dependence of the Ca2+-selective TRPV6 channel.
Microfluorimetry and patch-clamp experiments were performed on TRPV6-expressing HEK cells to determine whether this Ca(2+)-sensing Ca(2+) channel is constitutively active. Intact cells loaded with fura-2 had an elevated intracellular free Ca(2+) concentration ([Ca(2+)](i)), which decreased to the same level such as in non-transfected cells if external Ca(2+) was chelated by EGTA. Whole cell rec...
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ژورنال
عنوان ژورنال: RSC Medicinal Chemistry
سال: 2020
ISSN: 2632-8682
DOI: 10.1039/d0md00145g